We are a research group focused on understanding the origins, mechanisms, and impacts of RNA variation/diversity. While traditional views emphasize its adaptive value, we explore an alternative perspective: that much of this diversity may arise from molecular errors in gene expression. Our lab combines multi-omics data with molecular biology, bioinformatics, and evolutionary genomics to 1) refine the molecular error theory of RNA variation, 2) develop novel methods to discover functional RNA variants, 3) investigate how dysregulations in RNA variation contribute to diseases, and 4) discover atypical RNA variants that play roles in environmental adaptation.

We are committed to a research culture that is collaborative, curious, and inclusive. We value open-minded inquiry and strive to support all members of our lab regardless of background or identity.

Our lab is based on Bio-X institutes at SJTU, and we welcome you to learn more through our Research and Publications pages.