We are a research group focused on understanding the origins, mechanisms, and impacts of gene product diversity (e.g., alternative transcription and translation). While traditional views emphasize its adaptive value, we explore an alternative perspective: that much of this diversity may arise from molecular errors in gene expression. Our lab combines multi-omics data with molecular biology, bioinformatics, and evolutionary genomics to 1) refine the molecular error theory of gene product diversity, 2) investigate how dysregulations in RNA and protein diversity contribute to diseases, and 3) discover atypical gene products that play roles in environmental adaptation.
We are committed to a research culture that is collaborative, curious, and inclusive. We value open-minded inquiry and strive to support all members of our lab regardless of background or identity.
Our lab is based on Bio-X institutes at SJTU, and we welcome you to learn more through our Research and Publications pages.
2025.05.28 Congratulations to Ruoxi on successfully defending her undergraduate theses!
2025.05.27 Congratulations to Tianjiao on the publication of his circular RNA paper in npj Precision Oncology!
2025.05.26 Congratulations to Hanyue, Yijun, and Zhaolong on successfully defending their undergraduate theses!
2025.05.23 Welcome Zhizhou from UMich to visit Xu Lab!
2025.05.11 Congratulations to Tianjiao on successfully defending his PhD theses!
2025.04.08 Welcome Hao to Xu Lab!
2025.04.04 Congratulations to Lei on the publication of his fungal APA paper in Mycology!
2025.03.23 A memorable spring barbecue picnic for Xu Lab!
2025.02.26 Welcome Xianjia to Xu Lab!
2025.01.29 Happy Chinese New Year!
2025.01.18 Congratulations to Zheng on the publication of his m5C paper in Molecular Biology and Evolution!
